THERAPY DOSSIER · th-1bb460804bd3

Manual hindlimb stretching (static stretch-and-hold physical therapy protocol modelled on clinical practice)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25106555 ↗2014Reported harm

Hindlimb stretching alters locomotor function after spinal cord injury in the adult rat.

RatSpinal cord injuryContusionSprague-DawleyFemalen = 19 young adult female rats in total: acute stretch group n…Manual external application to the hindlimbs with the animal held supine and wrapped in a towelApproximately 30 min per session, comprising 1 full minute…Acute stretch group began at post-injury day 4; a chronic stretch subgroup of c…

Model: Moderate contusive spinal cord injury (12.5 g-cm) delivered at the T10 spinal cord level with the NYU Impactor after a single level laminectomy at T9

Daily stretching significantly impaired locomotor recovery. Hindlimb function declined over the first 4 weeks with a saw-tooth pattern of transient loss after each session; BBB scores improved from weeks 5 to 10 but remained below controls, and deficits persisted after stretching ceased at 8 weeks.…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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