Low-level light therapy induces mucosal healing in a murine model of dextran-sodium-sulfate induced colitis.
MouseChemical/toxinC57BL/6Intracolonic, applied endoscopically to the colonWavelengths of 440, 660 and 850 nm at 1 J/cm2; 850 nm was a…Initiated 1 day prior to induction of colitis
Model: Acute colitis induced by dextran sodium sulfate (DSS) over a 6 day induction period, studied across four blinded controlled experiments (model validation, efficacy and two dose optimisation studies)
Statistically significant improvement in disease severity was observed in the treatment groups compared with controls. All three wavelengths were effective and a clear dose-response curve was seen for 850 nm. On day 11 the colonoscopic score in sham-treated mice rose from 7.9 ± 1.3 to 12.2 ± 2.2, w…
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