THERAPY DOSSIER · th-2ae03b6b8624

Low-level light therapy (LLLT) delivered with a small diameter endoscope carrying an LED-based light source

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 8

6 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06893497 ↗Injury indicationPHASE4completed

Does Low-level Laser Therapy Protocol Affect the Efficacy of Treatment of Inferior Alveolar Nerve Injury After Maxillofacial Surgery

Inferior Alveolar Nerve Injuries

Enrolment: 55 · Results not recorded

NCT03031223 ↗Injury indicationNAunknown

Evaluation of Sensory-motor Response to Low-level Laser Therapy for the Treatment of Spinal Injuries

Spinal Cord Injuries

Enrolment: 30 · Results not recorded

NCT06956404 ↗Injury indicationNArecruiting

Transcranial Photobiomodulation in Older Adults With Traumatic Brain Injury: Effects on Cerebral Blood Flow and Cognition

Traumatic Brain Injury

Enrolment: 70 · Results not recorded

NCT07403695 ↗Injury indicationNAcompleted

Comparison Between Photobiomodulation Therapy on Nerve Repair Using Red and Infra-red Diode Lasers in Maxillofacial Region

Nerve Injury

Enrolment: 30 · Results not recorded

NCT03751306 ↗Injury indicationNAunknown

Sensory-Motor and Cardiorespiratory Rehabilitation Associated With Transcranial Laser Therapy in Patients With Central Nervous System Injury

Post Stroke · Spinal Injuries · Cerebral Palsy, Spastic · Post-Traumatic Headache

Enrolment: 90 · Results not recorded

NCT04823507 ↗Injury indicationPhase not recordedcompleted

Photobiomodulation for Concussions: Use of the ImPACT Test to Assess Improvement in Cognition and Symptomatology

Mild Traumatic Brain Injury

Enrolment: 35 · Results not recorded

NCT06086210 ↗NAcompleted

Efficacy of Low Level Laser Therapy in Ulnar Neuropathy at the Elbow

Ulnar Nerve Entrapment at Elbow

Enrolment: 68 · Results not recorded

NCT06248541 ↗NAunknown

The Effect of Low-Level Laser Therapy in Carpal Tunnel Syndrome

Carpal Tunnel Syndrome

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25101535 ↗2014Reported benefit

Low-level light therapy induces mucosal healing in a murine model of dextran-sodium-sulfate induced colitis.

MouseChemical/toxinC57BL/6Intracolonic, applied endoscopically to the colonWavelengths of 440, 660 and 850 nm at 1 J/cm2; 850 nm was a…Initiated 1 day prior to induction of colitis

Model: Acute colitis induced by dextran sodium sulfate (DSS) over a 6 day induction period, studied across four blinded controlled experiments (model validation, efficacy and two dose optimisation studies)

Statistically significant improvement in disease severity was observed in the treatment groups compared with controls. All three wavelengths were effective and a clear dose-response curve was seen for 850 nm. On day 11 the colonoscopic score in sham-treated mice rose from 7.9 ± 1.3 to 12.2 ± 2.2, w…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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