Effects of progesterone vs. dexamethasone on brain oedema and inflammatory responses following experimental brain resection.
RatTBIUnspecifiedSprague DawleyMalen = 75 adult male rats randomised into five groupsProgesterone 10 mg/kg (low dose) or 20 mg/kg (high dose); d…
Model: Surgical brain injury induced by experimental brain resection
The model consistently increased brain water content and disrupted the blood-brain barrier. Progesterone reduced astrocyte and microglia responses and attenuated brain oedema with preservation of the blood-brain barrier, and was as effective as dexamethasone in reducing brain oedema and inflammatio…
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