Protective effect of indomethacin in renal ischemia-reperfusion injury in mice.
MouseIschaemia-reperfusionRenalC57BL/6MaleIntraperitoneal injection1, 3, 5 and 7 mg/kgAdministered after clamping of the left renal pedicle; precise interval not sta…
Model: Renal ischaemia-reperfusion injury induced by clamping the left renal pedicle
Indomethacin showed a dose-dependent renoprotective effect. Mice given 5 mg/kg had a marked reduction in serum creatinine and significantly less tubular damage; 5 and 7 mg/kg reduced renal tumour necrosis factor alpha and serum interleukin 6; 3 and 5 mg/kg reduced the thromboxane B2 to 6-keto-prost…
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