L-carnitine protects against carboplatin-mediated renal injury: AMPK- and PPARα-dependent inactivation of NFAT3.
MixedChemical/toxinBALB/cMalen = 12 mice per group, except the compound C group with 16 mice…Intraperitoneal injection (in vivo)50 mg/kg in vivo; 5 mM in vitroPretreatment starting 2 days before the single carboplatin dose
Model: Carboplatin-induced renal tubular injury (single intraperitoneal carboplatin 75 mg/kg in vivo; 200 µM carboplatin challenge in renal tubular cells in vitro)
L-carnitine markedly reduced carboplatin-induced renal injury. Histological damage was milder, carboplatin-induced renal tubular cell apoptosis was inhibited by approximately 75%, and the carboplatin-induced rises in serum urea nitrogen and creatinine were significantly alleviated. Protection depen…
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