FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation.
MouseTBIWeight-drop / impact-accelerationC57BL/61 mg/kgImmediately before injury
Model: Focal cortical cryolesion; separate diffuse trauma model using weight drop contusion injury
FTY720 significantly lowered circulating lymphocyte numbers and attenuated immune cell invasion into damaged brain parenchyma, but did not improve lesion size or functional outcome in either the cryolesion or weight drop model at acute or chronic stages. Blood-brain barrier disruption and neuronal…
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