Effects of umbilical cord tissue mesenchymal stem cells (UCX®) on rat sciatic nerve regeneration after neurotmesis injuries.
RatOtherSasco Sprague DawleyMalen = Groups of 6 to 7 animals each in the acute (21 day) and chr…Local application at the injury site: infiltration into the interfascicular epineurium (UCX® alone) or placement in contact with the external epineurium (UCX® with Floseal®)5000 viable UCX® cells per neurotmesis lesion, delivered in…At the time of surgical reconstruction, immediately after the neurotmesis injury
Model: Sciatic nerve neurotmesis (complete transection) repaired by end-to-end cooptation with 7/0 monofilament nylon epineural sutures
Histology in the hyper-acute (day 3) and acute (day 21) phases showed that the UCX®-alone group had improved Wallerian degeneration, higher fibre organisation and less fibrosis. At 20 weeks, stereology showed significantly larger axon diameter and thicker myelin in the End-to-End Floseal UCX® group…
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