THERAPY DOSSIER · th-b7fb23e9edaa

Human umbilical cord tissue-derived mesenchymal stem cells (UCX®), alone or combined with Floseal® haemostatic sealant as vehicle

Biologic · Cell therapy (umbilical cord MSCs); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Cell therapy (umbilical cord MSCs); not a ChEMBL entity
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01873547 ↗Injury indicationPHASE3completed

Rehabilitation vs Umbilical Cord MSC Transplantation in Chronic Spinal Cord Injury

Spinal Cord Injury

Enrolment: 300 · Results not recorded

NCT07739043 ↗Injury indicationEARLY_PHASE1not yet recruiting

Allogeneic Umbilical Cord-Derived MSC (UC-MSC) in Traumatic Spinal Cord Injury

Spinal Cord Injury

Enrolment: 8 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25075157 ↗2014Mixed findings

Effects of umbilical cord tissue mesenchymal stem cells (UCX®) on rat sciatic nerve regeneration after neurotmesis injuries.

RatOtherSasco Sprague DawleyMalen = Groups of 6 to 7 animals each in the acute (21 day) and chr…Local application at the injury site: infiltration into the interfascicular epineurium (UCX® alone) or placement in contact with the external epineurium (UCX® with Floseal®)5000 viable UCX® cells per neurotmesis lesion, delivered in…At the time of surgical reconstruction, immediately after the neurotmesis injury

Model: Sciatic nerve neurotmesis (complete transection) repaired by end-to-end cooptation with 7/0 monofilament nylon epineural sutures

Histology in the hyper-acute (day 3) and acute (day 21) phases showed that the UCX®-alone group had improved Wallerian degeneration, higher fibre organisation and less fibrosis. At 20 weeks, stereology showed significantly larger axon diameter and thicker myelin in the End-to-End Floseal UCX® group…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

Loading the evidence…