G-CSF pretreatment aggravates LPS-associated microcirculatory dysfunction and acute liver injury after partial hepatectomy in rats.
RatEndotoxin/LPSLewisMalePretreatment before partial hepatectomy and lipopolysaccharide challenge
Model: 70% partial hepatectomy followed by lipopolysaccharide administration
G-CSF pretreatment worsened outcome. All rats given G-CSF plus lipopolysaccharide plus partial hepatectomy died within 4 h with severe inflammation, erythrocyte congestion, neutrophil infiltration, portal hypertension and pronounced microcirculatory disturbance, against 30% 24 h survival for lipopo…
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