High-density lipoprotein from patients with coronary heart disease loses anti-thrombotic effects on endothelial cells: impact on arterial thrombus formation.
MouseOtherSystemic treatment in mice; direct application in cell culture50 micrograms/ml in endothelial cell culture; in vivo dose…Treatment before laser-induced injury
Model: Laser-induced carotid artery injury and thrombus formation, with parallel human aortic endothelial cell culture experiments
HDL from healthy subjects delayed arterial thrombus formation and suppressed endothelial tissue factor while increasing tissue factor pathway inhibitor and tissue plasminogen activator via nitric oxide. HDL from patients with coronary heart disease or acute coronary syndrome lost these effects and…
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