THERAPY DOSSIER · th-25f339617c0f

High-density lipoprotein from healthy subjects and from patients with stable coronary heart disease or acute coronary syndrome

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25056722 ↗2014Mixed findings

High-density lipoprotein from patients with coronary heart disease loses anti-thrombotic effects on endothelial cells: impact on arterial thrombus formation.

MouseOtherSystemic treatment in mice; direct application in cell culture50 micrograms/ml in endothelial cell culture; in vivo dose…Treatment before laser-induced injury

Model: Laser-induced carotid artery injury and thrombus formation, with parallel human aortic endothelial cell culture experiments

HDL from healthy subjects delayed arterial thrombus formation and suppressed endothelial tissue factor while increasing tissue factor pathway inhibitor and tissue plasminogen activator via nitric oxide. HDL from patients with coronary heart disease or acute coronary syndrome lost these effects and…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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