Melatonin inhibits thermal injury-induced hyperpermeability in microvascular endothelial cells.
RatBurnUnspecifiedSprague-DawleyPretreatment of endothelial cell monolayers in vitroPretreatment before application of burn serum
Model: Thermal (burn) injury in rats with intravital microscopy of venules, and burn serum applied to rat lung microvascular endothelial cell monolayers
Burn increased vascular hyperpermeability, and burn serum increased monolayer permeability, adherens junction damage, stress fibre formation and reactive oxygen species generation. Melatonin attenuated each of these effects.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.