Effects of methylprednisolone and 4-chloro-3-hydroxyanthranilic acid in experimental spinal cord injury in the guinea pig appear to be mediated by different and potentially complementary mechanisms.
Guinea pigSpinal cord injuryCompressionFemaleIntraperitonealMethylprednisolone 150 mg/kg in split doses, or a single do…Methylprednisolone split doses between 0.5 and 6 h after injury, or a single do…
Model: Standardised lateral compression injury of the thoracic spinal cord under anaesthesia
Methylprednisolone 150 mg/kg in split doses reduced delayed loss of motor and sensory function without significantly lowering tissue quinolinic acid. A single 60 mg/kg dose at 5 h improved sensory function but the same dose at 10 h did not. A single dose of 4-chloro-3-hydroxyanthranilic acid at 5 h…
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