Farnesyltransferase inhibitor, tipifarnib, prevents galactosamine/lipopolysaccharide-induced acute liver failure.
MouseEndotoxin/LPSC57BL/6JMalen = n = 10 per group for survivalIntraperitoneal10 mg/kg60 minutes before the galactosamine and lipopolysaccharide challenge
Model: Acute liver failure induced by intraperitoneal D-galactosamine 400 mg/kg plus lipopolysaccharide 3 micrograms/kg
Four of ten vehicle-treated mice died within 24 h of challenge whereas no tipifarnib-treated mice died (p = 0.0289 by log-rank test). Tipifarnib prevented aminotransferase rises, cytokine and damage-associated molecular pattern increases, caspase 3 and PARP cleavage and JNK phosphorylation, and upr…
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