R115777 With Radiation Therapy and Temozolomide in Newly Diagnosed Glioblastoma
Adult Glioblastoma · Adult Gliosarcoma
Enrolment: 19 · Results not recorded
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Drug · Protein farnesyltransferase inhibitor
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Adult Glioblastoma · Adult Gliosarcoma
Enrolment: 19 · Results not recorded
Acute Myeloid Leukemia
Enrolment: 457 · Results not recorded
Urothelial Carcinoma
Enrolment: 19 · Results not recorded
Acute Myeloid Leukemia
Enrolment: 72 · Results not recorded
Thyroid Cancer · HNSCC · HRAS Mutant Tumor
Enrolment: 63 · Results not recorded
HNSCC
Enrolment: 45 · Results not recorded
Breast Cancer · Stage II Breast Cancer · Stage IIIA Breast Cancer · Stage IIIB Breast Cancer · Stage IIIC Breast Cancer
Enrolment: 60 · Results not recorded
Advanced Malignant Neoplasm
Enrolment: 74 · Results not recorded
Advanced Solid Tumor
Enrolment: 6 · Results not recorded
Cancer
Enrolment not recorded · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Acute liver failure induced by intraperitoneal D-galactosamine 400 mg/kg plus lipopolysaccharide 3 micrograms/kg
Four of ten vehicle-treated mice died within 24 h of challenge whereas no tipifarnib-treated mice died (p = 0.0289 by log-rank test). Tipifarnib prevented aminotransferase rises, cytokine and damage-associated molecular pattern increases, caspase 3 and PARP cleavage and JNK phosphorylation, and upr…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.