Role of ornithine decarboxylase in diallyl sulfide inhibition of colonic radiation injury in the mouse.
MouseRadiationC57BL/6JFemaleOral gavage200 mg/kg3 h before irradiation
Model: Single whole body gamma irradiation (0.5 to 10 Gy, 60Co) causing acute colonic mucosal injury
Diallyl sulfide significantly inhibited colonic nuclear aberration formation across 0.5 to 10 Gy in a dose-related manner and suppressed the sustained induction of DNA synthesis and ornithine decarboxylase after 6 Gy. It was ineffective when given after irradiation, and difluoromethylornithine abol…
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