Postexposure aerosolized heparin reduces lung injury in chlorine-exposed mice.
MouseChemical/toxinC57BL/6MaleAerosol inhalationAfter chlorine exposure, on return to room air
Model: Chlorine gas exposure at 400 ppm for 30 min or 600 ppm for 45 min in environmental chambers, then return to room air for 1 or 6 h
Chlorine exposure prolonged clotting time and clot formation time and increased D-dimers and bronchoalveolar thrombin-antithrombin complexes. Aerosolised heparin significantly reduced bronchoalveolar lavage protein and inflammatory cell numbers at 6 h after exposure.
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