THERAPY DOSSIER · th-e623c1a7d24a

Aerosolised heparin

Drug · Antithrombin-III activator (ACTIVATOR); inhibits coagulation

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Evidence & regulatory context

Mechanism: Antithrombin-III activator (ACTIVATOR); inhibits coagulation
Target: CHEMBL1950
Injury models: Chemical/toxin
Reported indication: Anticoagulation (thrombosis prophylaxis/treatment); systemic heparin is approved. Aerosolised/nebulised route for acute lung injury is NOT approved
First approval: 1982
Development stage: Heparin approved as anticoagulant; nebulised-for-ALI investigational (mixed evidence)
ChEMBL record: CHEMBL1201513 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Heparin; Unfractionated heparin; Calciparine
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05886998 ↗Injury indicationPHASE3completed

Nebulized Heparin for Prevention of Acute Lung Injury in Smoke Inhalation Injury

Smoke Inhalation Injury · Acute Lung Injury

Enrolment: 88 · Results not recorded

NCT05255848 ↗PHASE2/PHASE3unknown

Role of Nebulized Heparin in Non-severe and Severe COVID-19 Patients

COVID-19 Pneumonia

Enrolment: 180 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25038191 ↗2014Reported benefit

Postexposure aerosolized heparin reduces lung injury in chlorine-exposed mice.

MouseChemical/toxinC57BL/6MaleAerosol inhalationAfter chlorine exposure, on return to room air

Model: Chlorine gas exposure at 400 ppm for 30 min or 600 ppm for 45 min in environmental chambers, then return to room air for 1 or 6 h

Chlorine exposure prolonged clotting time and clot formation time and increased D-dimers and bronchoalveolar thrombin-antithrombin complexes. Aerosolised heparin significantly reduced bronchoalveolar lavage protein and inflammatory cell numbers at 6 h after exposure.

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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