Spinal cord transection-induced allodynia in rats--behavioral, physiopathological and pharmacological characterization.
RatSpinal cord injuryUnspecifiedSprague-DawleyMalen = 6 to 8 rats per group for behavioural time-courses; 9 trans…Subcutaneous for morphine, intraperitoneal for most agents, and intrathecal at L5-L6 in 20 microlitres of saline for ondansetronMorphine 1, 3, 10 mg/kg; tapentadol 10, 20 mg/kg; ketamine…Acute single administration 30 days after transection, once mechanical allodyni…
Model: Complete transverse section of the spinal cord at T8-T9 under deep isoflurane anaesthesia with absorbable haemostatic gel foam inserted; sham animals underwent laminectomy only
Transection produced sustained at-level mechanical and cold allodynia with a 100-fold lower pressure threshold than sham, hindpaw hyper-reflexia and prolonged upregulation of neuronal injury and glial activation transcripts. Morphine 3 to 10 mg/kg, tapentadol 20 mg/kg and ketamine 50 mg/kg raised t…
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