Hydrophobically-modified chitosan foam: description and hemostatic efficacy.
RatHaemorrhage/shockUncontrolledSprague-DawleyMaleTopical spray onto the injured liver surface, dimethyl ether propellantImmediately after hepatectomy
Model: Non-compressible severe liver injury by 14 plus or minus 3% partial hepatectomy with lactated Ringer resuscitation
HM-CS foam reduced total blood loss (29.3 plus or minus 7.8 mL/kg for HM-CS5 versus 90.9 plus or minus 20.3 mL/kg in controls, P less than 0.001) and improved 60 min survival from 0% in controls to 100% in the HM-CS5 group (P less than 0.001). Formulations with the highest hydrophobic modification…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.