THERAPY DOSSIER · th-f61dee1bf5b7

Hydrophobically modified chitosan (HM-CS) self-expanding foam, six formulations HM-CS1 to HM-CS6

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Haemorrhage/shock
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01373801 ↗Injury indicationNAunknown

Efficacy and Safety of HemCon Bandage Following Surgical Repair in Management of Postpartum Bleeding Due to Multiple Vaginal Lacerations

Postpartum Bleeding · Vaginal Lacerations · Cervical Lacerations

Enrolment: 85 · Results not recorded

NCT00707486 ↗PHASE3completed

Randomized, Self Controlled Clinical Study of Hemostatic Efficacy of the HemCon Dental Dressing

Tooth Extractions

Enrolment: 72 · Results not recorded

NCT03907111 ↗NAcompleted

Develop the Biologic-fibrotic Dressing on War Open Bleeding Wounds for Hemostasis (chitosan gauze)

Hemostasis

Enrolment: 10 · Results not recorded

NCT04884919 ↗NAunknown

Develop the First Aid Medical Supplies for Hemostasis and Bacteriostasis (chitosan dressing)

Cesarean Section

Enrolment: 40 · Results not recorded

NCT02837744 ↗Phase not recordedcompleted

Safety and Efficacy of Axiostat Chitosan Hemostatic Dressing on Radial Access After Percutaneous Procedure

Percutaneous Coronary Intervention · Angiography · Angioplasty

Enrolment: 70 · Results not recorded

NCT02918045 ↗NAcompleted

Dental Extractions Under Dual Antiplatelet Therapy: Comparison of Two Local Hemostatic Techniques (HemCon chitosan dressing)

Blood Coagulation Disorders

Enrolment: 60 · Results not recorded

NCT00707564 ↗NAwithdrawn

Hemostatic Efficacy of the HemCon Dental Dressing in a Population Treated With Anticoagulant Medications

Tooth Extractions

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25016441 ↗2014Reported benefit

Hydrophobically-modified chitosan foam: description and hemostatic efficacy.

RatHaemorrhage/shockUncontrolledSprague-DawleyMaleTopical spray onto the injured liver surface, dimethyl ether propellantImmediately after hepatectomy

Model: Non-compressible severe liver injury by 14 plus or minus 3% partial hepatectomy with lactated Ringer resuscitation

HM-CS foam reduced total blood loss (29.3 plus or minus 7.8 mL/kg for HM-CS5 versus 90.9 plus or minus 20.3 mL/kg in controls, P less than 0.001) and improved 60 min survival from 0% in controls to 100% in the HM-CS5 group (P less than 0.001). Formulations with the highest hydrophobic modification…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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