Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms.
RatOtherSprague-DawleyMalen = 5 rats per group for treatment; histology analysed on 2, 3,…Oral gavage5 or 15 mg/kg per day, dissolved in DMSO/corn oil 3:7Pretreatment once daily for 3 days before balloon injury, then continued after…
Model: Balloon catheter injury of the left common carotid artery (restenosis and neointimal hyperplasia model)
DMF dose-dependently reduced neointimal formation and Ki67 positivity after balloon injury and restored CD31 expression, consistent with improved re-endothelialisation. In vitro DMF arrested VSMCs at G0/G1 through p21 upregulation driven by Nrf2 (early) and p53 (late) and protected human aortic end…
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