The effects of ketamine, midazolam and ketamine/xylazine on acute lung injury induced by alpha-naphthylthiourea in rats.
RatChemical/toxinWistarMaleIntraperitonealKetamine 15 and 50 mg/kg; midazolam 2 and 4 mg/kg; ketamine…30 min prior to ANTU administration
Model: Alpha-naphthylthiourea (ANTU) induced acute lung injury, ANTU 10 mg/kg intraperitoneally
All agents significantly reduced pleural effusion formation at every dose. Ketamine significantly reduced inflammation, haemorrhage and oedema scores, while midazolam 2 mg/kg and ketamine/xylazine significantly reduced inflammation and oedema scores.
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