Hippocampal immediate early gene transcription in the rat fluid percussion traumatic brain injury model.
RatTBIFluid percussionLong-EvansMaleAcute post-traumatic period, within the 24 h following injury
Model: Lateral fluid percussion traumatic brain injury
Lateral fluid percussion injury increased c-fos and BDNF maximally 1-6 h after injury in the ipsilesional hippocampus and increased Bax bilaterally over the same window. MK801 attenuated the injury-induced increases in BDNF and Bax.
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