Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis.
MouseFractureTibiaC57BL/6malen = 62 male C57BL/6 mice; fractures created in 60; 52 analysed…intra-articular injection (local); subcutaneous osmotic pump (systemic IL-1Ra); intraperitoneal (systemic sTNFRII)Intra-articular IL-1Ra 0.9 mg in 6 uL; intra-articular sTNF…Local injection immediately following fracture; osmotic pumps implanted immedia…
Model: Closed intra-articular fracture of the left tibial plateau produced by compressive loading (10 N preload, loading at 20 N/s, indenter displacement limited to 2.7 mm) with no fixation or surgical intervention; assessment at 8 weeks post-injury
Local intra-articular IL-1Ra prevented cartilage degeneration, with no significant Mankin difference between fractured and contralateral limbs (p=0.37) and lower fractured-limb Mankin scores than saline (p=0.03). Local sTNFRII did not differ from saline (p=0.38). Systemic IL-1Ra worsened outcomes,…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.