Human NgR-Fc decoy protein via lumbar intrathecal bolus administration enhances recovery from rat spinal cord contusion.
RatSpinal cord injuryContusionSprague-Dawleyfemaleintracerebroventricular infusion; lumbar intrathecal bolus0.09-0.53 mg/kg/day (continuous intracerebroventricular inf…
Model: Spinal cord contusion injury; impact parameters not stated in the available text
Continuous intracerebroventricular infusion at 0.09-0.53 mg/kg/day improved neurological recovery, with effective doses doubling the percentage of rats able to bear weight on their hindlimbs. Intermittent lumbar bolus dosing at 0.14 mg/kg/day every 4 days promoted locomotor recovery at least as eff…
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