A Multicenter, Two Part Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AXER-204 in Subjects With Chronic Spinal Cord Injury
Chronic Spinal Cord Injury
Enrolment: 52 · Results not recorded
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Biologic
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Chronic Spinal Cord Injury
Enrolment: 52 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Spinal cord contusion injury; impact parameters not stated in the available text
Continuous intracerebroventricular infusion at 0.09-0.53 mg/kg/day improved neurological recovery, with effective doses doubling the percentage of rats able to bear weight on their hindlimbs. Intermittent lumbar bolus dosing at 0.14 mg/kg/day every 4 days promoted locomotor recovery at least as eff…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.