Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia.
RatIschaemia-reperfusionCerebral (MCAO/stroke)male
Model: Middle cerebral artery occlusion (MCAO) model of focal cerebral ischaemia; in vitro oxygen-glucose deprivation in cultured astrocytes and endothelial cells
Hydrogen sulfide augmented angiogenesis in the peri-infarct area and significantly improved functional outcome at 2 weeks in the rat MCAO model. Treated rats showed 2.31-fold more newly synthesised endothelial cells in the ischaemic lesion (p<0.01). In vitro, hydrogen sulfide increased endothelial…
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