Deferoxamine attenuates acute hydrocephalus after traumatic brain injury in rats.
Model: Lateral fluid-percussion traumatic brain injury under isoflurane with mechanical ventilation, right parietal craniotomy 5 mm diameter centred 4 mm posterior and 3 mm lateral to bregma, percussion pressure 2.5-3.5 atm. A separate iron model used intraventricular infusion of 200 uL saline or FeCl3 (0.5 mmol/L) at 14 uL/min
Traumatic brain injury caused acute hydrocephalus at 24 h (lateral ventricle volume 24.1 +/- 3.0 versus 9.9 +/- 0.2 mm3 in sham), and intraventricular FeCl3 alone produced comparable ventricular enlargement (25.7 +/- 3.4 versus 9.0 +/- 0.6 mm3, p<0.01). Deferoxamine reduced ipsilateral ventricular…
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