Futility study of deferoxamine in intracerebral hemorrhage
Intracerebral Hemorrhage
Enrolment: 42 · Results not recorded
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Drug · Iron chelating agent (CHELATING AGENT); direct interaction, disease efficacy true.
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Intracerebral Hemorrhage
Enrolment: 42 · Results not recorded
Intracerebral Hemorrhage
Enrolment: 180 · Results not recorded
Subarachnoid Hemorrhage
Enrolment: 2 · Results not recorded
Thalassemia Major · Hemosiderosis
Enrolment: 60 · Results not recorded
Ischemic Stroke, Acute
Enrolment: 62 · Results not recorded
Transfusion-dependent Beta-thalassemia · Cardiac Iron Overload
Enrolment: 32 · Results not recorded
Sickle Cell Disease · Iron Overload · Hemolytic Anemia
Enrolment: 212 · Results not recorded
Cardiovascular Diseases · Heart Diseases · Beta-Thalassemia
Enrolment: 20 · Results not recorded
Hepatocellular Carcinoma Non-resectable
Enrolment: 100 · Results not recorded
Immune Abnormalities
Enrolment: 25 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Endovascular perforation subarachnoid haemorrhage
Deferoxamine reduced brain iron, ferritin expression and neuronal cell death after subarachnoid haemorrhage.
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Model: Lateral fluid-percussion traumatic brain injury under isoflurane with mechanical ventilation, right parietal craniotomy 5 mm diameter centred 4 mm posterior and 3 mm lateral to bregma, percussion pressure 2.5-3.5 atm. A separate iron model used intraventricular infusion of 200 uL saline or FeCl3 (0.5 mmol/L) at 14 uL/min
Traumatic brain injury caused acute hydrocephalus at 24 h (lateral ventricle volume 24.1 +/- 3.0 versus 9.9 +/- 0.2 mm3 in sham), and intraventricular FeCl3 alone produced comparable ventricular enlargement (25.7 +/- 3.4 versus 9.0 +/- 0.6 mm3, p<0.01). Deferoxamine reduced ipsilateral ventricular…
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Model: Subarachnoid haemorrhage induced by a single injection of autologous blood into the prechiasmatic cistern
Cathepsin B/D and caspase-3 rose in the cortex after subarachnoid haemorrhage and peaked at 48 h. Intraperitoneal deferoxamine downregulated this elevated expression at 48 h and significantly ameliorated brain oedema, blood-brain barrier impairment, cortical apoptosis and behavioural deficits relat…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.