Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6 and Thy1-YFPMalen = 166 mice in the primary end-point study, at least 10 per gr…tPA intravenous by tail vein injection; edaravone intraperitonealtPA 10 mg/kg bolus; edaravone 3 mg/kgtPA at 0.5, 1 or 4 h after the insult; edaravone at 0, 1 and 2 h after the insu…
Model: Transient hypoxia-ischaemia: reversible ligation of the right common carotid artery with inhalation of 7.5% oxygen for 30 min, producing endogenous thrombosis and infarction
tPA at 0.5 h reduced mortality from 23.8% to 8.3% and infarct volume from 32.5% to 15.5%, and adding edaravone further reduced infarct to 6.4% (p=0.017) with 75% versus 40% 7-day survival. The benefit was lost with delay, and at 4 h mortality (26.6%) and infarct volume (30.5%) exceeded tPA alone.
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