Oral administration of quercetin is unable to protect against isoproterenol cardiotoxicity.
RatChemical/toxinWistar-HanMaleOral by gavage10 mg/kg dailyPretreatment for 7 days before isoprenaline
Model: Acute myocardial toxicity induced by subcutaneous isoprenaline (isoproterenol) 100 mg/kg
Quercetin did not protect against isoprenaline-induced falls in stroke volume, troponin T release, QRS-T junction elevation or histological damage; the only positive effect was normalisation of raised left ventricular end-diastolic pressure.
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