FTY720 attenuates paraquat-induced lung injury in mice.
MouseChemical/toxinC57BL/6n = Paraquat n=12; paraquat plus FTY720 n=12; FTY720 alone n=5;…Intraperitoneal0.1 mg/kgFirst dose 2 h after paraquat exposure
Model: Paraquat poisoning by intraperitoneal instillation of 30 mg/kg, causing acute lung injury progressing to fibrosis
FTY720 attenuated acute lung injury and subsequent fibrosis, lowering lung wet weight to body weight ratio, lavage protein and cytokines at day 3 and downregulating alpha-SMA, TGF-beta, VEGF and collagen I and III at day 28.
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