Early administration of tumor necrosis factor-alpha antagonist promotes survival of transplanted neural stem cells and axon myelination after spinal cord injury in rats.
RatSpinal cord injuryContusionSprague-DawleyFemaleEarly administration during the acute phase after injury
Model: Spinal cord contusion injury
Early etanercept suppressed TNF-alpha and apoptosis of transplanted neural stem cells, and combination therapy improved locomotor recovery, ventral horn neuron survival, cavity size, neurofilament-positive fibres and axon myelination.
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