Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation.
RatChemical/toxinWistar (specific pathogen-free)MaleIntraperitoneal46.7 mg/kgBeginning 15 min after nitrogen mustard
Model: Nitrogen mustard (mechlorethamine hydrochloride) 0.125 mg/kg in 0.1 ml instilled intratracheally under ketamine and xylazine anaesthesia
Pentoxifylline significantly reduced granulocyte infiltration, oedema, fibrin deposition and fibroplasia, lavage cell number and protein, HO-1 and lipocalin-2, and shifted macrophages from COX-2 and MMP-9 positive to CD163 and galectin-3 positive. It had no significant effect on nitrogen mustard-in…
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