Activation of Akt/FKHR in the medulla oblongata contributes to spontaneous respiratory recovery after incomplete spinal cord injury in adult rats.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleInfusion into the medulla oblongata
Model: Partial cervical spinal cord hemisection injuring the bulbospinal respiratory tract, with spontaneous recovery of the paralysed hemidiaphragm
Medullary PI3K inhibition blocked injury-induced Akt and FKHR phosphorylation and prevented the spontaneous respiratory recovery normally seen after partial cervical injury, without altering baseline contractile frequency or ventilatory reactivity.
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