Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury · Crush
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleInfusion into the medulla oblongata
Model: Partial cervical spinal cord hemisection injuring the bulbospinal respiratory tract, with spontaneous recovery of the paralysed hemidiaphragm
Medullary PI3K inhibition blocked injury-induced Akt and FKHR phosphorylation and prevented the spontaneous respiratory recovery normally seen after partial cervical injury, without altering baseline contractile frequency or ventilatory reactivity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
MouseCrushLimb / muscle crushC57BL/6Male
Model: Acute contusion of skeletal muscle in a mouse model
PI3K inhibition reduced expression of fibrosis markers and scar area in contused skeletal muscle and improved both fast-twitch and tetanic strength, indicating that PI3K-Akt-mTOR activation promotes collagen production and scarring after contusion.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
