Extracranial hypothermia during cardiac arrest and cardiopulmonary resuscitation is neuroprotective in vivo.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57Bl/6Malen = 15 per group for the hippocampal injury analysisBody temperature 28.8 plus or minus 1.5 degrees C during ca…During cardiac arrest and cardiopulmonary resuscitation, with body temperature…
Model: Cardiac arrest with cardiopulmonary resuscitation producing global cerebral ischaemia and peripheral organ injury
Extracranial hypothermia did not change peripheral organ damage but reduced hippocampal injury at 3 days (22.4 plus or minus 6.2% versus 45.7 plus or minus 9.1%, p=0.04), with a transient 2.1 degrees C fall in brain temperature after resuscitation.
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