THERAPY DOSSIER · th-f51c8281aec8

Extracranial (body) hypothermia

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03442608 ↗Injury indicationNAunknown

Long-term Therapeutic Hypothermia in Adult Patients With Poor-grade Aneurysmal Subarachnoid Hemorrhage

Hypothermia · Aneurysmal Subarachnoid Hemorrhage

Enrolment: 200 · Results not recorded

NCT00878644 ↗PHASE3completed

Therapeutic Hypothermia After Pediatric Cardiac Arrest (Out of Hospital)

Cardiac Arrest

Enrolment: 295 · Results not recorded

NCT00500825 ↗Phase not recordedcompleted

Influence of Therapeutic Hypothermia on Resting Energy Expenditure in Patients After Cardiopulmonary Resuscitation

Cardiopulmonary Resuscitation

Enrolment: 25 · Results not recorded

NCT05767476 ↗Phase not recordedrecruiting

Neurodevelopmental Outcome in Newborn With Hypoxic-ischemic Encephalopathy Treated With Therapeutic Hypothermia

Hypoxic Ischemic Encephalopathy

Enrolment: 70 · Results not recorded

NCT07028372 ↗Phase not recordedrecruiting

Long Term Follow-up of Cardiac Arrest Survivors Exposed to Ultra-rapid Cooling

Cardiac Arrest

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24865403 ↗2014Mixed findings

Extracranial hypothermia during cardiac arrest and cardiopulmonary resuscitation is neuroprotective in vivo.

MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57Bl/6Malen = 15 per group for the hippocampal injury analysisBody temperature 28.8 plus or minus 1.5 degrees C during ca…During cardiac arrest and cardiopulmonary resuscitation, with body temperature…

Model: Cardiac arrest with cardiopulmonary resuscitation producing global cerebral ischaemia and peripheral organ injury

Extracranial hypothermia did not change peripheral organ damage but reduced hippocampal injury at 3 days (22.4 plus or minus 6.2% versus 45.7 plus or minus 9.1%, p=0.04), with a transient 2.1 degrees C fall in brain temperature after resuscitation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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