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PRECLINICAL PUBLICATION · 2014

Systemic administration of atorvastatin improves locomotor functions and hyperacute-acute response after experimental spinal cord injury: an ultrastructural and biochemical analysis.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 24848171 ↗2014Reported benefit

Systemic administration of atorvastatin improves locomotor functions and hyperacute-acute response after experimental spinal cord injury: an ultrastructural and biochemical analysis.

RatSpinal cord injuryContusionSprague-Dawleymalen = 32 rats in total, 8 per group across four groupsIntraperitoneal0.2 mg/kg

Model: Weight-drop contusion spinal cord injury at T10 after single-level laminectomy

Atorvastatin improved locomotor recovery and significantly reduced IL-1 beta, IL-6 and lipid peroxide levels compared with injured controls.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.