Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model.

Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model.

Model: Aristolochic acid I induced acute nephropathy

Autophagy inhibitors increased mitochondrial apoptosis of renal tubular epithelial cells but partially mitigated severe tubulointerstitial injury, indicating apoptosis is not the main driver of this model.

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