Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Chemical/toxin · Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
MouseChemical/toxinBALB/cIntraperitoneal injectionGiven after the onset of acute pancreatitis; tissues analysed 24 h after the la…
Model: Severe acute pancreatitis induced by L-arginine, or by cerulein plus lipopolysaccharide
3-Methyladenine ameliorated systemic organ injury in both severe acute pancreatitis models, impairing autophagic flux and reducing inflammatory activation and cytokine levels.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
MouseChemical/toxinBALB/cGiven concurrently with aristolochic acid I
Model: Aristolochic acid I induced acute nephropathy
Autophagy inhibitors increased mitochondrial apoptosis of renal tubular epithelial cells but partially mitigated severe tubulointerstitial injury, indicating apoptosis is not the main driver of this model.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
RatOtherSprague-DawleyMaleIntraperitonealBefore seawater exposure
Model: Seawater aspiration-induced acute lung injury
Seawater aspiration triggered autophagy; inhibition of autophagy with 3-MA partly ameliorated seawater-induced acute lung injury, with reduced lung weight coefficient, reduced TNF-alpha in bronchoalveolar lavage fluid and increased PaO2.
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.
