PRECLINICAL PUBLICATION · 2014

Granulocyte colony-stimulating factor improves neuron survival in experimental spinal cord injury by regulating nucleophosmin-1 expression.

Mouse / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Granulocyte colony-stimulating factor (G-CSF)

PMID 24829950 ↗2014Reported benefit

Granulocyte colony-stimulating factor improves neuron survival in experimental spinal cord injury by regulating nucleophosmin-1 expression.

MouseSpinal cord injuryHemisection / partialfemale

Model: Spinal cord hemisection, with an in vitro neuronal mechanical injury model

G-CSF promoted locomotor recovery and inhibited neuronal apoptosis, and the nucleophosmin 1 inhibitor partially blocked its neuroprotective effect in vitro.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.