Morphine self-administration following spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleymaleIntravenous self-administration1.5 mg per lever press, up to 30 mg per daySelf-administration started at 24 h, 14 days or 35 days after injury
Model: Moderate spinal contusion injury
Contused animals took less morphine in the acute phase but at 14 and 35 days took nearly all available morphine, with significant weight loss and no effect on locomotor recovery, indicating addictive potential is not reduced after injury.
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