Therapeutic effect of long-term melatonin treatment on the course and fatal outcome of modeled acute radiation sickness.
MouseRadiationC57Bl/6maleOral, in drinking water5 mg/litre in drinking water, giving a daily dose of 0.9-1.…Started on day 3 after irradiation
Model: Whole-body gamma irradiation at 9.5-10.0 Gy delivered at 7.7-17.1 cGy/min, approximately LD97/30
Melatonin improved survival by more than 20 percent, reduced leukopenia at the peak of illness and increased blood leukocyte count by about 40 percent by day 12.
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