Curcumin attenuates liver warm ischemia and reperfusion-induced combined restrictive and obstructive lung disease by reducing matrix metalloprotease 9 activity.
RatIschaemia-reperfusionHepaticSprague-Dawleymalen = 30 rats divided evenly into three groups15 mg/kg per dayFirst dose 15 min before ischaemia
Model: Hepatic warm ischaemia by 30 min occlusion of the hepatic artery and portal vein followed by 48 h reperfusion, with secondary lung injury
Curcumin improved all measured lung function indices and reduced serum alanine transaminase, lung tumour necrosis factor alpha and matrix metalloproteinase 9 activity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.