N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma.
RatSpinal cord injuryContusionSprague-Dawleyfemalen = 141 female rats used in total; 120 for acute mitochondrial…Intraperitoneal, followed by continuous subcutaneous osmotic minipump delivery (Alzet model 2ML1) for the long-term arm75, 150, 300 or 600 mg/kg for acute mitochondrial studies;…First dose 15 min after injury
Model: Upper lumbar contusion spinal cord injury
NACA improved mitochondrial bioenergetics dose-dependently with maximum effect at 300 mg/kg, maintained mitochondrial glutathione near normal, and one week of delivery improved hindlimb function and increased tissue sparing.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.