The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain.
RatTBIPenetrating / ballisticAfter injury
Model: Penetrating stab wound to adult cerebral cortex
Chloroquine or colchicine reduced mononuclear phagocyte numbers in damaged brain and blocked reactive astrogliosis and neovascularisation, but also slowed debris clearance from the wound site. Dexamethasone neither reduced inflammatory cell numbers nor affected phagocytosis, astrogliosis, neovascul…
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