Glibenclamide reduces secondary brain damage after experimental traumatic brain injury.
RatTBIControlled cortical impactSprague-Dawleyn = 14 animals for brain water content and 10 per group for con…Bolus injection followed by continuous delivery via osmotic pumpsBolus 15 min after injury
Model: Parietal craniotomy followed by controlled cortical impact injury
Glibenclamide reduced brain water content (80.47 versus 80.83 percent) and contusion volume at all time points, for example 172.53 versus 299.20 cubic millimetres at 24 h, but did not alter acute physiological parameters or beam-walking performance.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.